Objective To explore the application value of enhanced recovery after surgery （ERAS） in the perioperative period of senile patients with chronic subdural hematoma.Methods A total of 70 cases of senile patients with chronic subdural hematoma of single side treated in Beijing Aerospace General Hospital from April 2016 to June 2020 were selected as the research objects. The patients were divided into observation group（35 cases）and control group（35 cases），according to whether they received ERAS or not. The control group adopted routine perioperative intervention measures. The intervention measures in observation group were guided by the concept of enhanced recovery after surgery. The time of hospitalization and the incidence of complications after operation and the expenses of hospitalization and the DDDs were compared between the two groups. Glasgow outcome score （GOS） was compared at 1 month after operation.Results There was a significant difference in the length of stay between the observation group and the control group （P =0.032）. The length of stay in the observation group was less than that in the control group （10.15±0.27 vs 13.90±0.25）. There was significant difference in hospitalization expenses between the observation group and the control group （P =0.014）. The hospitalization expenses of the observation group was less than that of the control group （0.90±0.13 vs 1.30±0.09）. In terms of DDDs， the difference between the observation group and the control group was statistically significant （P =0.002）， and the observation group was lower than the control group （2.11±0.33 vs 4.79±0.27）. Postoperative observation group has wound infection in 1 case， the control group wound infection occurred in 2 cases， the difference was not significant （P =0.555）. The observation group has no lung infection case， the control group occurred in 4 cases， the control group was higher than the observation group， the difference was statistically significant （P =0.031）. The observation group has no deep vein thrombosis， in 2 cases of the control group， the difference between the two groups has no statistical significance （P =0.151）. Postoperative GOS score， the observation group was higher than the control group （4.31±0.33 vs. 3.99±0.27）， the difference was statistically significant （P =0.022）.Conclusion The application of the Enhanced Recovery After Surgery in the perioperative treatment and management of chronic subdural hematoma can effectively reduce the postoperative complications， the hospitalization time， the expenses of hospitalization， the DDDs and improve the prognosis of patients. ［Journal of International Neurology and Neurosurgery, 2021, 48(1): 9-12］