Alzheimer’s disease （AD） is the main cause of senile dementia， and at present， there are still no effective treatment regimens for AD. Since natural compounds have the advantages of moderate effect and few adverse effects， the use of natural compounds in the treatment of neurodegenerative diseases has become a research hotspot in recent years. It has been confirmed that resveratrol has a potential therapeutic effect on AD， but the mechanism of action of resveratrol in alleviating the onset of AD remains unknown. Studies have shown that resveratrol undergoes metabolic transformation after absorption in animals and plants and thus exerts a therapeutic effect through its metabolites. In order to explore the mechanism of action of resveratrol in exerting a therapeutic effect in vivo， it is necessary to summarize the metabolites generated from resveratrol and the mechanism of their effect on AD. This article reviews the potential effect and clinical significance of resveratrol metabolites in the treatment of AD， so as to provide new ideas for effective use of resveratrol metabolites as candidates for AD treatment and development of novel derivatives. ［Citation:Journal of International Neurology and Neurosurgery, 2021, 48(4): 382-386.］