Cranial autonomic symptoms （CAS）， which are typical for trigeminal autonomic cephalalgias （TACs）， are not used for the diagnosis of migraine but not rare in patients with migraine. Migraine with CAS （MwCAS） may be a clinical subtype between migraine and cluster headache， with different clinical features as compared to migraine without CAS. These differences suggest a higher level of neural sensitization in MwCAS. There are differences and connections between MwCAS and TACs. Trigeminal-autonomic reflex and the hypothalamus underlie the pathogenesis of both disorders. ［Citation:Journal of International Neurology and Neurosurgery,2021,48(04):406-409.］