Objective To analyze the expression of serum superoxide dismutase （SOD）， endothelin-1 （ET-1） and S100 protein in gastrodin injection combined with argatroban during neural interventional endovascular embolization level of influence.Methods Sixty patients who underwent interventional neurovascular embolization in our hospital from August 2018 to December 2019 were selected as the research object.Randomly divided into two groups， 30 cases in the control group， using conventional treatment + argatroban， 30 cases in the observation group， plus gastrodin injection based on the control group.Statistical analysis of the serum SOD， ET-1 and S100 protein expression data before and after treatment and the incidence of complications in the two groups.Results Serum SOD levels were significantly increased after treatment in the two groups （P<0.05）， and ET-1 and S100 protein levels were significantly reduced （P<0.05）. In addition， the observation group's serum SOD， ET-1 and S100 levels 1d， 3d and 7 d after treatment The difference in protein level is also statistically significant （P<0.05）.The incidence of cerebral vasospasm in the observation group was 3.33%， which was significantly lower than 23.33% in the control group. The difference was statistically significant （P<0.05）； the observation group was 6.67% and 6.67% of hydrocephalus， electrolyte imbalance and cerebral infarction， respectively And 3.33%， lower than the 16.67%， 13.33% and 10.00% of the control group， the difference was not statistically significant （P>0.05）.Conclusions Gastrodin injection combined with argatroban can enhance the cardiovascular and cerebrovascular antioxidant capacity of patients， improve persistent cell apoptosis， protect vascular endothelium， and effectively reduce the incidence of postoperative vasospasm. ［Citation:Journal of International Neurology and Neurosurgery, 2021, 48(4): 366-369.］