4种常用阿尔茨海默病评测量表与提高后的服药依从性相关研究
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广州市第一人民医院(华南理工大学附属第二医院)脑系内科,广东 广州 510180

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何敏超(1981-),男,主治医师,博士,主要从事老年性痴呆及服药依从性的相关研究。Email:heminchaokaoyan@163.com。

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A study on the relationship between four neuropsychological scales and medication adherence in patients with Alzheimer’s disease
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Department of Neurology, Guangzhou First People’s Hospital (The Second Affiliated Hospital of South China University of Science and Engineering), Guangzhou, Guangdong 510180, China

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    摘要:

    目的 探讨常用的4种阿尔茨海默病神经心理评测量表与提高后的服药依从性是否具有相关性。方法 纳入2014年6月—2017年12月该院门诊及住院的31例阿尔茨海默病患者进行前瞻性研究。消除服药依从性的主观消极因素(医务人员、患者及照料者),改善患者服药依从性。同时,进行阿尔茨海默病评定量表认知部分、日常生活能力量表、神经精神症状问卷、基于临床医师对病情变化印象及照料者访谈量表的评测,检验两者相关性,并纳入影响依从性的客观因素进行偏相关关系分析。最后具体分析阿尔茨海默病评定量表认知部分各条目与服药依从性的相关性。结果 4种量表均与服药依从性均无相关性(P >0.05);偏相关分析也未显示出相关性(P >0.05)。阿尔茨海默病评定量表的命令和结构性2个条目分数与服药依从性具有弱相关性(P ≤0.05,相关系数分别为0.201及0.177)。结论 现有的阿尔茨海默病评测量表不能很好的评测阿尔茨海默病患者的服药依从性。服药依从性可能与实践能力相关。 [国际神经病学神经外科学杂志, 2021, 48(1): 40-45]

    Abstract:

    Objective To investigate whether four commonly used neuropsychological scales for Alzheimer’s disease are correlated with increased medication adherence in patients.Methods A prospective study was performed on 31 patients with Alzheimer’s disease in the outpatient and inpatient departments from June 2014 to December 2017. Medication adherence was improved by removing multiple subjective negative factors associated with medical providers, patients, and caregivers. The cognitive subscale of the Alzheimer’s Disease Assessment Scale, the Activities of Daily Living Scale, the Neuropsychiatric Inventory Questionnaire, and the scale based on clinician’s impression of conditions and caregiver interview were used for evaluation. A correlation analysis was carried out, and the objective factors affecting adherence were included for partial correlation analysis. Finally, the correlation between each item of the cognitive subscale of the Alzheimer’s Disease Assessment Scale and medication adherence was analyzed.Results None of the four scales was correlated with medication adherence (P >0.05), and the partial correlation analysis showed no significant associations (P >0.05). The scores of Commands and Constructional Praxis items of Alzheimer’s Disease Assessment Scale were weakly correlated with medication adherence (P <0.05, correlation coefficients: 0.201 and 0.177, respectively).Conclusions Existing Alzheimer’s Disease Assessment Scale is not suitable for the measurement of the medication adherence in patients with Alzheimer’s disease. Medication adherence may be related to patient’s practice.Journal of International Neurology and Neurosurgery, 2021, 48(1): 40-45]

    表 2 阿尔茨海默病评定量表各部分与服药依从率的相关关系Table 2
    图1 阿尔茨海默病患者服药依从性的变化Fig.1
    图2 阿尔茨海默病患者4种神经心理评测量表的变化Fig.2
    表 1 阿尔茨海默病评测量表与服药依从率的相关及偏相关关系Table 1
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何敏超456.4种常用阿尔茨海默病评测量表与提高后的服药依从性相关研究[J].国际神经病学神经外科学杂志,2021,48(1):40-45111HE Min-Chao222. A study on the relationship between four neuropsychological scales and medication adherence in patients with Alzheimer’s disease[J]. Journal of International Neurology and Neurosurgery,2021,48(1):40-45

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  • 收稿日期:2020-09-04
  • 最后修改日期:2021-01-06
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  • 在线发布日期: 2021-06-03
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