特发性震颤听力障碍特点及其本质分析
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1.曲靖市第二人民医院神经内科,云南 曲靖 655000;2.曲靖市第二人民医院院办,云南 曲靖 655000;3.昆明医科大学附属第二医院神经内科,云南 昆明 650000

作者简介:

侯立军(1977-),男,医学硕士,副主任医师,从事神经系统变性疾病和运动障碍疾病研究。Email:hlj_o@sohu.com。通信作者:侯立军与马立为共同通信作者。

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2020年云南省科技厅-云南中医药大学应用基础联合专项基金资助项目(202001AZ070001-080)


Characteristics and essential analysis of hearing impairment in essential tremor
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1.Department of Neurology, Second People’s Hospital of Qujing, Qujing, Yunnan 655000, China;2.Hospital Office, Second People’s Hospital of Qujing, Qujing, Yunnan 655000, China;3.Department of Neurology, The Second Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650000, China

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    摘要:

    目的 部分特发性震颤(ET)患者存在听力障碍,但是针对性研究较少。通过对ET患者听力障碍特点的研究,推测ET本质特征,为ET的临床诊疗提供可供参考的策略。方法 采用平行组设计,选取曲靖市第二人民医院神经内科住院部和门诊73名ET患者(146耳)和60名健康体检对照者(120耳),分别进行简易智力状态检查量表(MMSE)评分、问卷调查、纯音听力测试(PTA)和畸变产物耳声发射(DPOAE)检测,同时测定DPOAE的幅值。结果 调查问卷中ET组听力下降耳数与对照组比较,差异有统计学意义(P =0.027);客观听力测试中,ET组DPOAE和PTA检出听力下降耳数与对照组比较,差异有统计学意义(P =0.019, P =0.046)。问卷调查中ET组耳鸣发生率与对照组比较,差异有统计学意义(P =0.013);ET组者在高频耳鸣发生率与对照组比较,差异有统计学意义(P =0.000)。ET病程与DPOAE下降幅值之间关系回归分析结果显示,两者呈线性相关(r =0.948, P =0.005)。结论 听力障碍可能是ET的另一个经典非运动症状(NMS),推测ET可能为神经系统变性疾病。国际神经病学神经外科学杂志, 2021, 48(1): 46-49]

    Abstract:

    Objective Some patients with essential tremor (ET) have hearing impairment. However, there are few targeted studies. The objective of this article is to speculate the essential characteristics of ET through the study of the hearing characteristics of ET, and to provide reference strategies for the clinical diagnosis and treatment of ET.Methods A parallel group design was adopted. A total of 73 ET patients (146 ears) and 60 healthy controls (120 ears) from the inpatient and outpatient sections in the Department of Neurology of The Second People’s Hospital of Qujing were enrolled in this study. Mini-Mental State Examination (MMSE) scoring, questionnaire survey, pure tone audiometry (PTA), and distortion product otoacoustic emissions (DPOAE) were performed, and the amplitude of DPOAE was measured at the same time.Results The questionnaire survey showed that the number of ears with hearing loss in the ET group was significantly higher than that in the control group (P =0.027). The objective hearing tests showed that the number of ears with hearing loss in the ET group was significantly higher than that in the control group, according to the DPOAE and PTA results (P =0.019 and 0.046). According to the questionnaires, the incidence of both tinnitus and high-frequency tinnitus in the ET group was significantly higher than that in the control group (P =0.013 and 0.000). The regression analysis of the correlation between the course of ET and the decreasing amplitude of DPOAE showed that there was a linear correlation between them (r=0.948, P=0.005).Conclusions Hearing impairment may be another typical non-motor symptom (NMS) of ET. It is speculated that ET may be a neurodegenerative disease. [Journal of International Neurology and Neurosurgery, 2021, 48(1): 46-49]

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侯立军,马立,耿荔蓉,岳晓丽,朱榆红,李燕456.特发性震颤听力障碍特点及其本质分析[J].国际神经病学神经外科学杂志,2021,48(1):46-49111HOU Li-Jun, MA Li, GENG Li-Rong, YUE Xiao-Li, ZHU Yu-Hong, LI Yan222. Characteristics and essential analysis of hearing impairment in essential tremor[J]. Journal of International Neurology and Neurosurgery,2021,48(1):46-49

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  • 收稿日期:2020-07-14
  • 最后修改日期:2021-01-06
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  • 在线发布日期: 2021-06-03
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