Astrocytes, only types of cells which containing glycogen in the brain, can offer neurons energy substrates besides glucose to offset the injury induced by insufficient energy. Insufficient energy metabolism is a potentially reversible biomarker in the early stage of sporadic Alzheiner’s disease. it may associate with abnormal insulin receptor dysfunction in the brain. The decrease production of energy substrates in astrocytes potentiates oxidative stress in the neurons. Improve the insulin resistence in the brain can indirectly save neuron from death by produce more energy substrates in astrocytes .