Aim: To investigate the effects of NaoMaiTai on neuron apoptosis and the expression of Akt，bcl-2,Bax，caspase3 in local cerebral ischemic reperfusion rats. Methods: Sixty male Sprague-Dawley rats were randomized into six groups(n=10)： sham-operated group， MCAO group，MCAO+ NaoMaiTai (2.24、1.12、0.56 g·kg-1) group and MCAO+nimodipin (10mg·kg-1)group. Focal cerebral ischemia/reperfusion model in rats were made by transient occlusion of the middle cerebral artery for 90 minutes followed by 24 h reperfusion. NaoMaiTai were intragastric administered daily before five days operation. At the 24th hour after reperfusion, the brains were obtained for TUNEL staining, Akt，bcl-2,Bax and caspase3 expression was detected by immunohistochemistry method. Results: In the NaoMaiTai groups, the apoptotic cells were significantly decreased(P 0.01). The protein expression of Bax and caspase3 were lower, while the Akt and bcl-2 protein expression were significantly increased in NaoMaiTai group than the MCAO group(P<0.01). Conclusion: NaoMaiTai can prevent apoptosis in local cerebral ischemic reperfusion model rats due to the enhanced expression of Akt and bcl-2, decreased expression of Bax and caspase3.