The pathogenesis of epilepsy is complicated.It is confirmed that the processes for epileptic focus formation consume time relatively by the synaptic plasticity therapy、two-hit therapy and "kindling" therapy. It is a essential feature for the epileptic focus formation that there is degeneration within central nervous system especially hippocampal neurons during the processes.It bring about the most promising news for epilepsy prevention to neuroprotective therapy by improving the metabolism and stoping the degeneration 、sclerosis of hippocampal neurons. We reviewed the progress on study in this field.