Objective: The occurrence of intracranial aneurysms (IA) is closely related to genetic factors; However, research has shown that circular RNA (circRNA) is involved in vascular remodeling and inflammation regulation, and its role in the pathogenesis of IA is not yet clear. Therefore, this study aims to screen for circRNAs with differential expression in intracranial aneurysms and analyze their biological significance. Method: Sixteen clinical samples (10 IA tissues and 6 superficial temporal artery controls) were included, and DECs were screened using Illumina high-throughput sequencing technology; Combining the differences in visualization expression between volcano and heat maps, GO and KEGG joint enrichment analysis were applied to explore the functional associations of DECs; Further validate the expression levels of candidate circRNAs using qPCR. Result: A total of 28 850 DECs were identified (with 10 081 upregulated and 18 769 downregulated); KEGG analysis showed that IA related DECs were significantly enriched in the circadian rhythm, AMPK, and Hedgehog signaling pathways (P<0.001); QPCR validation showed that hsa_circ_0003967 and hsa_circ_0063305 were significantly upregulated in IA tissues (p<0.01); However, hsa_circ_0003091 and hsa_circ_0001742 were significantly down regulated (p<0.01), suggesting that these related signaling pathways such as cell adhesion, AMPK signaling pathway, circadian rhythm signaling pathway, Hedgehog signaling pathway, etc. may be involved in the pathological process of IA. Conclusion: Differential expression of circRNA is an important molecular feature in the occurrence of IA, and candidate molecules such as hsa_circ_0003967 may drive the formation of intracranial aneurysms by intervening in circadian rhythms, Hedgehog signaling pathways, and other signaling pathways, providing new clues for the mechanism research and targeted therapy of IA.