Glioma as the most common primary brain tumor in the central nervous system has the characteristics of high mortality, high recurrence rate, and poor prognosis. At present, there is a lack of sustainable and effective monitoring and nursing means for glioma patients after discharge. Healthcare workers are often unable to provide continuous, professional and personalized interventions for patients, which will delay the follow-up treatment and rehabilitation training of glioma patients. Digital therapeutics are evidence-based, clinically evaluated software to treat, manage, and prevent a broad spectrum of diseases and disorders. Existing evidence suggests that digital therapeutics that combines multiple aspects of patient support during cancer treatment (psychological support, education, exercise, and nutrition), can help patients improve the quality of life through remote symptom monitoring. Digital therapeutics can be applied to support and improve traditional care of several neurological dysfunctions. This is mainly reflected in better realization of personalized treatment, real-time monitoring, and improved adherence. This article reviewed the application of digital therapeutics in tumor treatment and improvement of neurological functions, and put forward its clinical application in glioma was proposed. Finally, we analyzed the prospects and limitations of digital therapeutics in the future.