磁感应热疗在脑胶质瘤治疗中的研究进展
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1.清华大学;2.北京大学人民医院

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Research Progress of Magnetic Induction Hyperthermia in the Treatment of Glioma
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1.Tsinghua University;2.Peking University People'3.'4.s Hospital Department

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    摘要:

    磁感应热疗(Magnetic Induction Hyperthermia, MIH)是一种新兴的物理治疗方案。该治疗方法通过将磁性纳米颗粒靶向输送至肿瘤区域,并利用外部交变磁场激活这些颗粒产生热量,实现对肿瘤细胞的选择性热损伤。研究表明,MIH治疗的优势在于其能够精确控制加热区域,减少对周围正常组织的损伤,同时激活热休克蛋白和免疫反应,增强抗肿瘤效果。本文综述了MIH在动物实验和临床试验中的研究进展,包括其作用机制、安全性、疗效等内容。通过分析现有文献,我们发现MIH治疗在提高患者生存期和生活质量方面显示出巨大潜力,但仍需进一步研究以解决治疗参数选择、安全性评估和长期效果监测等问题。随着材料科学和生物医学工程的不断进步,MIH有望成为脑胶质瘤综合治疗策略中的重要组成部分。

    Abstract:

    Magnetic Induction Hyperthermia (MIH) is an emerging physical therapy approach. This treatment method targets the delivery of magnetic nanoparticles to the tumor area and activates these particles to generate heat using an external alternating magnetic field, achieving selective thermal damage to tumor cells. Research has shown that the advantage of MIH therapy lies in its ability to precisely control the heating area, reduce damage to surrounding normal tissues, activate heat shock proteins and immune responses, and enhance anti-tumor effects. This article reviews the research progress of MIH in animal experiments and clinical trials, including its mechanism of action, safety, efficacy, and other aspects. Through analyzing existing literature, we found that MIH treatment has shown great potential in improving patient survival and quality of life, but further research is still needed to address issues such as treatment parameter selection, safety assessment, and long-term effect monitoring. With the continuous advancement of materials science and biomedical engineering, MIH is expected to become an important component of the comprehensive treatment strategy for glioblastoma.

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  • 收稿日期:2024-10-10
  • 最后修改日期:2024-12-05
  • 录用日期:2024-12-09
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