Abstract:Magnetic Induction Hyperthermia (MIH) is an emerging physical therapy approach. This treatment method targets the delivery of magnetic nanoparticles to the tumor area and activates these particles to generate heat using an external alternating magnetic field, achieving selective thermal damage to tumor cells. Research has shown that the advantage of MIH therapy lies in its ability to precisely control the heating area, reduce damage to surrounding normal tissues, activate heat shock proteins and immune responses, and enhance anti-tumor effects. This article reviews the research progress of MIH in animal experiments and clinical trials, including its mechanism of action, safety, efficacy, and other aspects. Through analyzing existing literature, we found that MIH treatment has shown great potential in improving patient survival and quality of life, but further research is still needed to address issues such as treatment parameter selection, safety assessment, and long-term effect monitoring. With the continuous advancement of materials science and biomedical engineering, MIH is expected to become an important component of the comprehensive treatment strategy for glioblastoma.