中南大学湘雅医院神经内科
国家自然科学基金项目（面上项目，重点项目，重大项目）湖南省重点研发项目
- ZHENG LAN 1
- YI Fang 2
- Gu Wenping 3
1.Department of Neurology, Xiangya Hospital, Central South University;2.Department of Geriatric Neurology, Xiangya Hospital, Central South University;3.Department of Neurology, Xiangya Hospital
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- 参考文献 | | | | |
脑小血管病（cerebral small vessel disease，CSVD）是一类影响全脑的疾病，其患病率和疾病负担均较高，然而，关于该病的病因和治疗尚缺乏明确的认识。心率变异性（heart rate variability，HRV）作为一种非侵入性指标，用于定量评估自主神经功能，它反映了自主神经的平衡状态，并与血压控制、炎症反应及物质代谢等方面有着密切的关联。既往有研究发现，心率变异性的降低可能与脑小血管病的发生和进展有关，但结论并不一致。本综述旨在总结心率变异性与脑小血管病的影像学及临床表现的相关研究，并进一步探讨其可能的致病机制，以期为脑小血管病的预防和治疗提供新的方向。
Cerebral Small Vessel Disease (CSVD) is a widespread brain-affecting condition with significant prevalence and burden. Despite this, its etiology and treatment remain unclear.Heart rate variability (HRV), a non-invasive marker, quantitatively assesses autonomic nervous system function. It mirrors the nervous system's equilibrium and is closely linked to blood pressure regulation, inflammatory responses, and metabolic processes.Prior research suggests that decreased heart rate variability could be linked to the onset and progression of cerebral small vessel disease, though findings are inconsistent.This review summarizes the research on the relationship between heart rate variability and the imaging, and clinical presentations of cerebral small vessel disease, and explores its potential pathogenic mechanisms, aiming to inform novel directions for its prevention and treatment.
