Glioma is the most common malignant tumor of central nervous system with the highest mortality.Like other malignancies, gliomas originate from genetic mutations in cells.Studies have shown that the growth of a cell with a gene mutation into a malignant tumor with all phenotypes requires an abnormal development process involving cell proliferation, differentiation, stemness and cell-cell interaction.In this process, tumor cells "commandeer" a large number of normal developmental regulatory signaling pathways.Wnt/β-catenin signaling pathway is a highly conserved signaling pathway that mediates the interaction between adjacent cells. It is widely involved in the precise regulation of normal development and the occurrence and development of malignant tumors.In this review, the Wnt/β-catenin signaling pathway and its role and mechanism in glioma are reviewed, and the current status of Wnt/β-catenin signaling pathway as a target intervention and treatment of glioma is reviewed.