急性期破裂颅内宽颈动脉瘤一期支架辅助治愈性栓塞的临床研究
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昆明医科大学第二附属医院脑血管病科

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云南省教育厅科学研究基金项目


Clinical study of stent-assisted curative embolization in acutely ruptured intracranial wide-necked aneurysms
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Cerebrovascular Disease, The Second Affiliated Hospital, Kunming Medical University

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    摘要:

    目的 分析一期采用支架辅助弹簧圈治愈性栓塞急性期破裂颅内动脉瘤的疗效及安全性。方法回顾性研究2017年01月-2022年10月昆明医科大学第二附属医院脑血管病科收治的205例采用血管内治疗的颅内动脉瘤破裂至蛛网膜下腔出血患者,收集临床资料包括一般情况、手术方法、Raymond分级评估即刻及末次随访栓塞率、围手术期及随访期并发症,改良Rankin量表评估临床预后。结果 205例患者支架辅助弹簧圈栓塞(SAC)组77例,单纯弹簧圈栓塞(NSC)组128例。SAC组术后即刻RaymondⅠ级栓塞率76.6%,NSC组75.0%,差异无统计学意义。188例获得临床随访,85例患者获得至少1次DSA随访。SAC组末次随访Ⅰ级栓塞97.4%(37/38),NSC组91.5%(43/47);SAC组3例复发(3/38,7.9%),NSC组9例复发(9/47,19.0%),差异均无统计学意义。SAC组术中总并发症发生率(13.0%,10/77)与NSC组比较(9.4%,12/128)差异无统计学意义;术后1月内SAC组7例(9.1%)发生动脉瘤再破裂出血,较NSC组(1例,0.8%)显著增高,但总并发症发生率(18/77,23.4%)与NSC组(20/128,15.6%)比较差异无统计学意义。至随访终点,两组总死亡率与预后良好率差异无统计学意义。结论 SAC治疗急性期破裂动脉瘤安全有效,支架的使用未增加缺血事件发生的风险,抗血小板药物亦不增加术中出血性事件发生率,但仍应警惕由于动脉瘤未完全致密栓塞时抗血小板治疗带来的术后出血风险。

    Abstract:

    To analyze the safety and efficacy of stent-assisted coil curative embolization in acute-stage ruptured intracranial aneurysms. Methods 205 patients with acute-stage ruptured intracranial aneurysms who were treated by endovascular treatment at Department of Cerebrovascular Disease, The Second Affiliated Hospital, Kunming Medical University between January 2017 and October 2022 were included in this retrospective analysis. The clinical relevant data of all patients were collected included general conditions, surgical methods, modified Raymond-Roy occlusion classification at end of procedure and last follow-up, perioperative and follow-up complications and clinical outcome. Results 205 patients had stent-assisted coil embolization (SAC) group and 128 no-stent coiling (NSC) group. Immediate postoperative embolization rate ( Raymond grade I occlusion )was 76.6% in SAC group and 75.0% in NSC group. There was no statistically significant difference between the two groups. Clinical follow-up data were available for 188 patients, with 85 patients receiving at least once DSA follow-up. At last follow-up, grade I embolization rate was 97.4% (37/38) in SAC group and 91.5% (43/47) in NSC group , and 3 aneurysms recurrence (3/38,7.9%) in SAC group and 9 recurrence (9/47,19.0%) in NSC group, none of which were statistically significant. There was no significant difference in the SAC group in overall intraoperative complication rate (13.0%, 10/77) versus the NSC group (9.4%, 12/128).7 patients (9.1%) occurred aneurysm rebleeding in the SAC group within 1 month after surgery, which was significantly higher compared with the NSC group (1 case, 0.8%), but the overall complication rate between the SAC group(18/77,23.4%) and the NSC group (20/128,15.6%) was no statistical differences. At the follow-up end point, The total mortality rate and the good prognosis rate between the two groups were no significant difference.Conclusions SAC is safe and effective in treating intracranial ruptured aneurysms in the acute phase. The use of antiplatelet agents does not increase the incidence of intraoperative hemorrhagic events, but we should still be alert to the risk of postoperative bleeding due to antiplatelet therapy when the aneurysm was incomplete embolization.

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  • 收稿日期:2023-10-07
  • 最后修改日期:2024-01-04
  • 录用日期:2024-01-05
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