Abstract:Spinal cord injury (SCI) is a severely disabling central nervous system injury, posing a significant global challenge in clinical medicine. The spinal cord exhibits limited regenerative capabilities and diminished neuroplasticity. The formation of cystic cavities and glial scars subsequent to SCI obstruct nerve conduction, rendering the repair of SCI a formidable undertaking. Currently, effective treatments for SCI remain elusive. "Spinal cord fusion" is an emerging technique designed to repair SCI. This innovative approach primarily leverages fusion agents, a sharp knife and electrical stimulation to expedite nerve fusion and repair, facilitate the regeneration of nerve axons, and reconstruct the complete nerve conduction circuit. The ultimate goal is to restore the lost functions resulting from SCI. By discussing this important research progress and the involved neurological mechanisms, this paper reviews SCI-related studies over the years and introduced the new concept of “Spinal Cord Fusion”. Our aim is to help solve the problem of SCI repair as soon as possible, as well as hoping to bring new breakthrough for the treatment of paraplegia after SCI.