Traumatic Brain Injury (TBI) is a kind of mechanical injury caused by external force, including primary and secondary injuries. Drug therapy that inhibits cell death from secondary injury is of great significance for improving the prognosis and quality of life in TBI patients. Ferroptosis is a kind of programmed cell death induced by iron-dependent lipid peroxidation, which is involved in the physiological and pathological regulation of a variety of acute and chronic nervous system diseases. Studies have shown that ferroptosis is involved in the neuronal death mechanism of TBI secondary injury and is associated with long-term prognosis after TBI. This paper summarizes potential drugs for the treatment of TBI patients with targeted ferroptosis. Through targeted and precise intervention strategies for TBI, ferroptosis of nerve cells after secondary TBI injury is ultimately prevented, so as to protect nerve tissue and reduce the disability rate and fatality rate of patients.