创伤性脑损伤（Traumatic Brain Injury, TBI）是由外力撞击引起的一种机械损伤性疾病，包括原发性损伤和继发性损伤。抑制继发性损伤的细胞死亡的药物疗法对改善TBI患者的预后和生活质量具有重要意义。铁死亡是一种铁依赖的脂质过氧化诱发的细胞程序性死亡，参与多种急性和慢性神经系统疾病的生理病理调控。研究发现，铁死亡参与了TBI继发性损伤的神经元死亡机制，并与TBI后的长期预后相关。本文总结了靶向铁死亡治疗TBI患者的潜在药物，通过对TBI采取针对性和精准化策略干预，最终防止TBI继发性损伤后的神经细胞铁死亡，达到保护神经组织，减轻患者伤残率和病死率的目的。
Traumatic Brain Injury (TBI) is a kind of mechanical injury caused by external force, including primary and secondary injuries. Drug therapy that inhibits cell death from secondary injury is of great significance for improving the prognosis and quality of life in TBI patients. Ferroptosis is a kind of programmed cell death induced by iron-dependent lipid peroxidation, which is involved in the physiological and pathological regulation of a variety of acute and chronic nervous system diseases. Studies have shown that ferroptosis is involved in the neuronal death mechanism of TBI secondary injury and is associated with long-term prognosis after TBI. This paper summarizes potential drugs for the treatment of TBI patients with targeted ferroptosis. Through targeted and precise intervention strategies for TBI, ferroptosis of nerve cells after secondary TBI injury is ultimately prevented, so as to protect nerve tissue and reduce the disability rate and fatality rate of patients.