胶质瘤中蛋白质异常糖基化的研究进展
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山西省太原市双塔西街29号山西省人民医院

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山西省自然科学基金资助项目POFUT1通过异常岩藻糖基化影响胶质母细胞瘤发生发展的作用机制研究(20210302124386);山西省自然科学基金资助项目肿瘤治疗电场对胶质母细胞瘤免疫微环境影响及机制的研究(20210302124380)。2


Advances in abnormal glycosylation of proteins in glioma
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    摘要:

    蛋白质的糖基化修饰是一种十分常见的翻译后修饰,影响着超过一半的已知真核生物蛋白质的功能。蛋白质异常糖基化是恶性肿瘤的普遍特征,蛋白质异常糖基化往往会通过糖蛋白的基因突变、核苷酸糖供体的变化、糖基转移酶的表达或定位的异常等多种方式导致糖脂和糖蛋白在结构和含量上异常,进而导致蛋白质的功能异常,有助于促进癌症的恶性进展。由于胶质瘤的恶性度高,预后差,因此我们急需寻找胶质瘤恶性进展中的关键分子事件。众多的研究发现蛋白质异常糖基化在胶质瘤的发生、发展及不良预后中起着至关重要的作用,同时与胶质瘤相关的糖基化在早期诊断和治疗中也被广泛研究。本综述主要介绍与胶质瘤相关的N-连接糖基化,O-连接糖基化,糖基磷脂酰肌醇(GPI)锚定这三种糖基化形式,阐述其发生机理以及具体作用机制,并探讨异常糖基化在检测和治疗胶质瘤中的临床潜力,以期为解决胶质瘤预后差的现状提供理论基础。

    Abstract:

    Glycosylation modification of proteins is a very common post-translational modification that affects the function of more than half of known eukaryotic proteins. Abnormal glycation of proteins is a common feature of malignant tumors. Aberrant protein glycosylation often leads to abnormalities in the structure and content of glycolipids and glycoproteins in a variety of ways, including genetic mutations in glycoproteins, changes in nucleotide sugar donors, and abnormal expression or localization of glycosyltransferases, which in turn lead to abnormal protein function and help promote malignant cancer progression. Because of the high malignancy and poor prognosis of glioma, there is an urgent need to search for key molecular events in the malignant progression of glioma. Numerous studies have found that abnormal protein glycosylation plays a crucial role in glioma development, progression and poor prognosis, while glycosylation associated with glioma has been extensively studied in early diagnosis and treatment. Therefore, this review focuses on three forms of glioma-related glycosylation, N-linked glycosylation, O-linked glycosylation and Glycosylphosphatidyl inositol (GPI) anchor, describes their mechanisms of occurrence and specific mechanisms of action, and explores the clinical potential of abnormal glycosylation in the detection and treatment of glioma, with the aim of providing a theoretical basis for addressing the current situation of poor prognosis of glioma.

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  • 收稿日期:2022-04-16
  • 最后修改日期:2023-05-14
  • 录用日期:2022-09-27
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