Abstract Objective：To investigate the prediction effect of preoperative platelet-related parameters on tumor recurrence in patients with glioma. Methods:The clinicopathological data of 93 patients with glioma admitted to 909th Hospital of JLF from 2015 to 2017 were retrospectively analyzed.According to whether the tumor recurred during the follow-up period, the patients were divided into non-recurrence group (n=52) and recurrence group (n=41).ROC curve was used to analyze the predictive effects of platelet count (PLT), platelet distribution width (PDW), platelet specific volume (PCT), mean platelet volume / mean platelet volume (MPV/PLT) on tumor recurrence.Univariate and multivariate Cox analysis of tumor recurrence factors.Kaplan-meier survival analysis was performed based on the results of multivariate analysis.Results:The PLT and PCT in patients without recurrence were lower than those in patients with recurrence (t=-2.490, -2.189, P<0.05). MPV and MPV/PLT in patients without recurrence were higher than those in patients with recurrence (t=2.184, 4.252, P<0.05).ROC analysis showed that the area under the PLT curve was 0.630 (95%CI= 0.517～0.743, P=0.032), and the threshold was 216×109/L. The MPV area was 0.633 (95%CI= 0.518～0.747, P=0.029), and the threshold was 8.65fl. The area under the MPV/PLT curve was 0.731 (95%CI=0.626～0.835, P<0.001),and the threshold was 0.040.Multivariate analysis showed that tumor grade (Ⅲ～Ⅳ), MPV ≤ 8.65fl, MPV/PLT ≤ 0.040 were independent risk factors for postoperative tumor recurrence (HR=1.657, 1.803, 1.694, 95%CI=0.778～3.530, 0.730～4.450, 0.011～0.067, P<0.05).Survival curve analysis showed that the recurrence rate of patients with MPV ≤ 8.65 FL was higher than that of patients with MPV>8.65 FL (Long Rank=10.990, P=0.001). Patients with MPV/PLT ≤ 0.040 had a higher 3-year recurrence rate than patients with MPV/PLT>0.040 (Long Rank=6.289, P=0.012).