抗Hu 抗体相关副肿瘤综合征合并吉兰-巴雷综合征1例报告
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1.福建医科大学附属第二医院;2.福建

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福建医科大学校启航基金项目(2020QH1122)


Anti-Hu antibody associated paraneoplastic syndrome with Guillain-Barre syndrome: a case report
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    摘要:

    副肿瘤综合征是一组与恶性肿瘤相关,由肿瘤产物(包括异位激素)异常的免疫反应或其他不明原因引起内分泌、神经、消化、血液、骨关节、皮肤等系统发生病变。抗Hu 抗体相关副肿瘤综合征(Hu-PNS)是抗 Hu 抗体阳性的神经副肿瘤综合征(paraneoplastic neurologic syndromes,PNS) ,最多见于小细胞肺癌,临床表现多种多样,现就我院收治的表现为吉兰-巴雷综合征、抗利尿激素异常分泌综合征的抗 Hu 抗体阳性的小细胞肺癌一例报道如下,旨在提高对本病的认识,减少误诊和漏诊。

    Abstract:

    Paraneoplastic syndrome is a group related to malignant tumors, which is caused by abnormal immune response of tumor products (including ectopic hormones) or other unknown reasons, including endocrine, nervous, digestive, blood, bone and joint, skin and other system lesions. Paraneoplastic Neurologic syndromes (PNS) are anti-HU antibody positive paraneoplastic neurologic syndromes (PNS), most commonly seen in small cell lung cancer, with various clinical manifestations. In order to improve the understanding of this disease and reduce misdiagnosis and missed diagnosis, a case of small cell lung cancer with positive anti-HU antibody presenting as Guillain-Barre syndrome and abnormal secretion of antidiuretic hormone syndrome in our hospital is reported as follows.

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  • 收稿日期:2021-12-27
  • 最后修改日期:2022-01-18
  • 录用日期:2022-03-23
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