Abstract:Spinal cord injury (SCI) is one of the most destructive traumatic diseases of human beings. Meanwhile, it is a global treatment problem. It is difficult for neurons to regenerate after injury. SCI will lead to high disability rate and mortality rate which brings huge economic burden not only to the family and but also to society. The classical Wnt/ β-catenin signal pathway is an important signal transduction system during the process of SCI. Current studies have confirmed that a variety of exogenous stimuli, such as silencing information regulator 2 homologous protein 1 (SIRT1)、laminin-like protein (Netrin)、microRNA(miRNA)、heat shock protein(HSP), can activate this pathway and regulate the expression of downstream target genes. Hence, it is beneficial to reduce autophagy and apoptosis of spinal cord neurons after SCI, inhibit inflammation, promote nerve cell proliferation and axon regeneration, decrease scar formation, and finally realize the aim of repairing SCI. This article concludes the molecular mechanism of SCI protection based on Wnt/ β-catenin signaling pathway in recent 3 years, in order to provide ideas for discovering new therapeutic targets of SCI.