Objective To investigate the association of inflammatory factors， immunoglobulins， and T lymphocyte subsets with postherpetic neuralgia in patients with herpes zoster.Methods A total of 80 patients with herpes zoster who attended Department of Neurology， Miluo Peoples Hospital， between October 2020 and October 2022 were enrolled， and according to the presence or absence of postherpetic neuralgia， they were divided into comorbidity group with 32 patients and non-comorbidity group with 48 patients. The two groups were compared in terms of general data， pain mediators （plasma P substance， β-endorphin， calcitonin gene-related peptide， neurotensin， and nerve growth factor induction protein）， inflammatory factors （C-reactive protein， interleukin-6， tumor necrosis factor-α， and procalcitonin）， immunoglobulins （immunoglobulin A， immunoglobulin G， and immunoglobulin M）， complement C3， complement C4， T lymphocyte subsets （CD3⁺， CD4⁺， CD8⁺， and CD4⁺/CD8⁺）. The Pearson correlation coefficient was used to identify the correlation of inflammatory factors， immunoglobulins， and T lymphocyte subsets with postherpetic neuralgia.Results There were no significant differences between the two groups in general data and the levels of tumor necrosis factor-α， procalcitonin， and T lymphocytes （P>0.05）. Compared with the non-comorbidity group， the comorbidity group had significantly higher levels of plasma substance P， calcitonin gene-related peptide， nerve growth factor induction protein， C-reactive protein， and interleukin-6 （P<0.05） and significantly lower levels of β-endorphin， neurotensin， immunoglobulin A， immunoglobulin G， immunoglobulin M， complement C3， and complement C4 （P<0.05）. The Pearson correlation analysis showed that C-reactive protein and interleukin-6 were positively correlated with plasma substance P， calcitonin gene-related peptide， and nerve growth factor induction protein （P<0.05） and were negatively correlated with β-endorphin and neurotensin （P <0.05）. Immunoglobulin A， immunoglobulin G， immunoglobulin M， complement C3， and complement C4 were negatively correlated with plasma substance P， calcitonin gene-related peptide， and nerve growth factor induction protein （P<0.05） and were positively correlated with β-endorphin and neurotensin （P<0.05）.Conclusions Patients with herpes zoster often have the comorbidity of postherpetic neuralgia， which is associated with the overexpression of inflammatory factors and low immune function.