Limb-girdle muscular dystrophy （LGMD） is a group of hereditary myopathies characterized by weakness of proximal muscles （pelvic and scapular muscles） and has three inheritance patterns of autosomal dominant inheritance， autosomal recessive inheritance， and X-linked inheritance. LGMD is highly inheritable and has high clinical heterogeneity， which often leads to missed diagnosis and misdiagnosis. At present， there is still a lack of effective drugs for LGMD， leading to poor prognosis and bringing huge burdens to the family and society. In order to guide the screening for high-risk LGMD carriers and provide related genetic counseling， the Chinese expert consensus on LGMD carrier screening suitable for the situations in China has been formulated based on related studies and guidelines in China and globally， so as to further promote the standardized prevention and control of LGMD. ［Journal of International Neurology and Neurosurgery, 2024, 51(5): 61-67］