Currently， most patients diagnosed with phenylalanine hydroxylase （PAH） deficiency through neonatal screening have progressed from childhood into young adulthood or even full adulthood. The transition period of adolescence is a critical phase in the comprehensive life-cycle management of PAH deficiency， with an emphasis on the cultivation of self-management awareness and skills and the transition from passive management to self-management. There are many difficulties in the management of this transition period， and there is still a lack of specific expert consensus on this issue. In order to facilitate the transition to adulthood treatment for adolescents with PAH deficiency， the experts from 12 centers across China have fully discussed the issues in the transitional management of adolescents， reached a consensus， and proposed 11 recommendations from the aspects of age range， phenylalanine concentration， dietary management， frequency monitoring， complication management， developmental assessment， and genetic counseling， in order to further optimize the survival outcome and quality of life of patients with phenylketonuria. ［Journal of International Neurology and Neurosurgery, 2024, 51(5): 30-35］