Glioma is the most common malignant tumor of the central nervous system， and it often originates from genetic mutations in cells. Studies have shown that the growth of a cell with a gene mutation into a malignant tumor cell with all phenotypes requires an abnormal development process involving cell proliferation， differentiation， stemness， and cell-cell interactions. In this process， tumor cells "commandeer" a large number of regulatory signaling pathways for normal development， including the Wnt/β-catenin signaling pathway， which is a highly conserved signaling pathway during evolution that mediates the interaction between adjacent cells and is widely involved in the precise regulation of normal development and the development and progression of malignant tumors. This article reviews the Wnt/β-catenin signaling pathway and its role and mechanism in glioma and describes the prospect of the Wnt/β-catenin signaling pathway as a target for the intervention and treatment of glioma. ［Journal of International Neurology and Neurosurgery, 2024, 51(4): 77-84］