焦亡机制及其在胶质瘤中的作用研究进展
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1.兰州大学第二临床医学院,甘肃 兰州 730030;2.兰州大学第二医院神经外科,甘肃 兰州 730030;3.兰州大学第二医院神经病学研究所,甘肃 兰州 730030

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潘亚文,Email:panyawen666@sohu.com。

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Research advances in the mechanism of pyroptosis and its role in glioma
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1.The Second Medical College of Lanzhou University, Lanzhou, Gansu 730030, China;2.Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China;3.Institute of Neurology, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China

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    摘要:

    胶质瘤是中枢神经系统最常见的恶性肿瘤,不断探索其有效的诊疗策略具有重要意义。目前焦亡作为一种新的炎症性程序性细胞死亡方式,在胶质瘤中已有大量的研究揭示其过程与机制。该文综述了细胞焦亡的分子机制,包括炎症小体的激活通路、执行焦亡的Gasdermin家族,以及焦亡相关通路和靶点在胶质瘤发展和诊疗中的应用和挑战,寻求通过细胞焦亡探索新的胶质瘤治疗策略以提高患者预后。 [国际神经病学神经外科学杂志, 2024, 51(4): 69-76]

    Abstract:

    Glioma is the most common malignant tumor of the central nervous system, and it is of great significance to explore effective diagnosis and treatment strategies. Pyroptosis, as a new pattern of inflammatory programmed cell death, has been extensively studied in glioma to reveal its process and mechanism. This article reviews the molecular mechanisms of pyroptosis, including the pathway of inflammasome activation, the Gasdermin family that performs pyroptosis, and the application and challenges of pyroptosis-related pathways and targets in the development, diagnosis, and treatment of glioma, so as to explore new treatment strategies for glioma through pyroptosis and improve the prognosis of patients. [Journal of International Neurology and Neurosurgery, 2024, 51(4): 69-76]

    表 2 焦亡相关分子在胶质瘤中的研究进展Table 2
    表 1 焦亡与凋亡的对比Table 1
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王旭东,梁强,周景寰,孙超,潘亚文456.焦亡机制及其在胶质瘤中的作用研究进展[J].国际神经病学神经外科学杂志,2024,51(4):69-76111WANG Xudong, LIANG Qiang, ZHOU Jinghuan, SUN Chao, PAN Yawen222. Research advances in the mechanism of pyroptosis and its role in glioma[J]. Journal of International Neurology and Neurosurgery,2024,51(4):69-76

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  • 收稿日期:2023-10-24
  • 最后修改日期:2024-04-04
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  • 在线发布日期: 2024-09-27
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