Objective To investigate the involvement patterns of brain networks in frontal glioma using the connectomics technology， as well as the association between brain networks and cognitive function in patients with frontal glioma.Methods A retrospective analysis was performed for 45 patients with frontal glioma who were diagnosed and treated in The First Affiliated Hospital of Nanjing Medical University （Jiangsu Provincial People’s Hospital）， and the connectomics technology was used to create an individualized brain network atlas and analyze the involvement patterns of frontal glioma on traditional functional structures and nontraditional functional networks. In a prospective study， imaging and neuropsychological data were collected from 10 patients to analyze the association between functional brain networks and cognitive function in frontal glioma.Results In the retrospective study， among the 45 patients， 33 （73.33%） had the involvement of traditional functional brain structures （including corticospinal tract and language regions） and 43 （95.56%） had the involvement of nontraditional functional brain networks， mainly the central executive network （51.11%） and the salience network （44.44%）. In the prospective study， among the 10 patients， 7 （70%） had the involvement of the central executive network and 6 （60%） had the involvement of the salience network； the 10 patients had a mean preoperative Mini-Mental State Examination score of 19.63±8.51 and a mean Montreal Cognitive Assessment score of 14.34±7.62， suggesting that they had varying degrees of cognitive decline.Conclusions Frontal glioma involves not only traditional functional structures but also nontraditional functional brain networks， and impairment of nontraditional functional networks often leads to cognitive dysfunction in patients.