This article reports two patients with the variant of Guillain-Barré syndrome （GBS） with peripheral facial paralysis as the main manifestation. Both patients had peripheral facial paralysis as the initial presentation， among whom one patient had bilateral peripheral facial paralysis with pain， and the other patient had left peripheral facial paralysis with the symptoms such as dizziness， somnolence， and poor appetite. No abnormalities were found on early EMG for the two patients. One patient was found to have albuminocytologic dissociation in cerebrospinal fluid， and the other patient tested positive for serum anti-GQ1b antibody IgM. They were diagnosed with the variant of GBS. Both patients received intravenous drip of human blood immunoglobulin and were discharged after the symptoms were improved. For patients with peripheral facial paralysis as the initial presentation， simple facial neuritis or other diseases with peripheral facial paralysis as the initial presentation should be considered， including the variant of GBS， so as to give correct diagnosis and treatment.