Krabbe disease （KD） is a rare autosomal recessive hereditary lysosomal storage disorder caused by galactocerebrosidase deficiency， which leads to the accumulation of the toxic metabolites galactosylsphingosine within the central and peripheral nervous systems， thereby resulting in demyelinating lesions. KD has different onset features and clinical manifestations in different age groups， and the infantile form of KD often has an early age of onset and progresses rapidly， leading to early mortality， while the adult form exhibits significant heterogeneity， which often leads to missed diagnosis and misdiagnosis， bringing great challenges to clinical management. In order to assist clinicians in making informed decisions in the diagnosis and treatment of KD， the Chinese expert consensus on the diagnosis and treatment of KD was developed in detailed based on related studies and guidelines in China and globally， so as to improve the diagnosis and treatment of KD in China.