Traumatic brain injury （TBI） is a type of mechanical injury caused by the impact of external force， including primary and secondary injuries. Pharmacotherapy that inhibits cell death due to secondary injury is of great significance for improving the prognosis and quality of life of TBI patients. Ferroptosis is the process of programmed cell death induced by iron-dependent lipid peroxidation and is involved in the physiological and pathological regulation of a variety of acute and chronic nervous system diseases. Studies have shown that ferroptosis is involved in the mechanism of neuronal death due to TBI secondary injury and is associated with long-term prognosis after TBI. This article summarizes the potential drugs targeting ferroptosis for the treatment of TBI patients， and targeted and precise intervention strategies are adopted for TBI to prevent the ferroptosis of nerve cells after secondary TBI injury， protect nervous tissue， and reduce the disability and mortality rates of patients.