SOX9在神经胶质瘤中的作用研究进展
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1.兰州大学第二临床医学院,甘肃 兰州 730030;2.兰州大学第二医院神经外科,甘肃 兰州 730030;3.兰州大学第二医院神经病学研究所,甘肃 兰州 730030

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潘亚文,Email: panyawen666@sohu.com。

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Research advances in the role of SOX9 in glioma
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1.The Second Medical College of Lanzhou University, Lanzhou, Gansu 730030, China;2.Department of Neurosurgery, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China;3.Institute of Neurology, The Second Hospital of Lanzhou University, Lanzhou, Gansu 730030, China.

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    摘要:

    转录因子SOX9属于SOX家族中SOXE亚类,目前已有大量文献证实其表达与神经胶质瘤有关。神经胶质瘤是最常见的恶性脑肿瘤,而高级别胶质瘤患者的预后极差,因此研究神经胶质瘤发病机制同时寻找新的有效治疗靶点十分重要。SOX9转录因子通过多种信号通路调控下游靶标,影响神经胶质瘤的发生、进展、治疗和预后。SOX9的上调与神经胶质瘤的进展呈正相关,对胶质瘤预后不利,降低SOX9的表达在胶质瘤治疗中可能是有利的。同时多种microRNA通过下调SOX9的表达来间接影响胶质瘤的生长进程。现就SOX9的结构、功能及影响神经胶质瘤细胞表型的信号通路与机制进行综述,并展望未来临床上可能的治疗靶点。

    Abstract:

    The transcription factor SOX9 belongs to the SOXE subclass of the SOX family, and a large number of articles have shown that the expression of SOX9 is associated with glioma. Glioma is the most common malignant brain tumor, and patients with high-grade glioma have an extremely poor prognosis; therefore, it is very important to investigate the pathogenesis of glioma and find new effective therapeutic targets. The transcription factor SOX9 regulates downstream targets through a variety of signaling pathways, thereby affecting the development, progression, treatment, and prognosis of glioma. The upregulation of SOX9 is positively correlated with the progression of glioma, which is unfavorable to the prognosis of glioma, and the reduction in SOX9 expression may be beneficial to the treatment of glioma. Meanwhile, various microRNAs indirectly affect the progression of glioma by downregulating the expression of SOX9. This article reviews the structure and function of SOX9 and the signaling pathways and mechanisms of its effect on glioma cell phenotype and looks forward to the potential therapeutic targets in the future.

    表 1 SOX9对下游分子(通路)的影响Table 1
    图1 SOX9蛋白结构域示意图Fig.1
    图2 SOX9对胶质瘤表型的调控机制Fig.2
    表 2 miRNA通过调控SOX9对胶质瘤的影响Table 2
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王旭东,梁强,周景寰,王鸿宇,潘亚文456. SOX9在神经胶质瘤中的作用研究进展[J].国际神经病学神经外科学杂志,2024,51(1):59-66111WANG Xudong, LIANG Qiang, ZHOU Jinghuan, WANG Hongyu, PAN Yawen222. Research advances in the role of SOX9 in glioma[J]. Journal of International Neurology and Neurosurgery,2024,51(1):59-66

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  • 收稿日期:2023-06-09
  • 最后修改日期:2023-10-26
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  • 在线发布日期: 2024-04-09
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