This article reports a case of epidermoid cyst in a rare intracranial location， and a literature review is also performed. The epidermoid cyst was located in the anterior longitudinal fissure cistern of the brain. After preoperative evaluation， complete resection of the cyst contents and subtotal resection of the cyst wall were performed via the anterior longitudinal fissure approach， with no new symptoms reported. For the difficulty in preoperative diagnosis of epidermoid cysts in rare intracranial sites， different approaches should be used according to different sites. There is no significant difference in postoperative complications between epidermoid cysts in rare locations and those in common locations.