Post-stroke depression refers to the depressive state that occurs after stroke and is a common sequela of stroke， bringing serious economic burden to the families of patients and the society. In recent years， irisin has attracted much attention as a new type of antidepressive agent； however， no articles have summarized the mechanism of action of irisin in alleviating post-stroke depression. This article reviews related studies and discusses the anti-inflammatory mechanism of irisin in the treatment of post-stroke depression， such as improving energy metabolism， protecting the nerves， and regulating the levels of neurotransmitters， as well as the possibility of irisin as a treatment drug for post-stroke depression， in order to provide more drug options for clinical relief of post-stroke depression and a reference for further research. ［Journal of International Neurology and Neurosurgery, 2023, 50(6): 72-77］