1.河南省安阳地区医院放射科，河南 安阳 455000;2.河南护理职业学院，河南 安阳 455000;3.西安医学院第二附属医院影像科，陕西 西安 710038;4.河南省林州市肿瘤医院放射科， 河南 林州 456550
刘艳玲（1980—），女，科主任，副主任医师，硕士学位，研究方向为神经肿瘤影像学，Email:664146386@qq.com。
潘奇（1983—），男，科主任，副主任医师，博士学位，研究方向为头颈部CT及MRI基础，Email:1287346579@qq.com。
陕西省科技厅重点研究计划（2021SF-271）；陕西省教育厅服务地方专项（22JC056）；西安医学院第二附属医院院级课题（2020KY0105）。
1.Department of Radiology， Anyang District Hospital， Anyang， Henan 455000， China;2.Henan Vocational College of Nursing， Anyang， Henan 455000， China;3.Department of Medical Imaging， The Second Affiliated Hospital of Xi"an Medical University， Xi'an， Shaanxi 710038， China;4.Department of Radiology， Linzhou Tumor Hospital， Linzhou， Henan 456550， China
- 摘要 |
- 图/表 |
- 访问统计 |
- 参考文献 |
- 相似文献 |
- 引证文献 |
- 资源附件 |
- 音频文件 |
- 视频文件
目的 探讨合成MRI技术鉴别高级别脑胶质瘤（HCG）术后复发与放射性脑损伤的应用价值。方法 收集2018年1月—2022年12月在安阳地区医院和西安医学院第二附属医院就诊的HCG术后放疗后患者41例，所有患者均接受合成MRI扫描和合成MRI对比增强扫描，并经二次手术病理证实或MRI随访确诊。测量病灶实质区、周围水肿区的增强前T1值（T1-pre）、T2值（T2-pre）和增强后T1值（T1+c），比较复发组和损伤组间各参数的差异。并绘制ROC曲线评价各参数对复发和损伤的鉴别诊断效能。结果 最终纳入37例，其中21例为复发，16例为放射性脑损伤。复发组和脑损伤组实质区与水肿区T1-pre、T2-pre比较，差异均无统计学意义（均P＞0.05）。复发组实质区和水肿区T1+c低于损伤组，增强前后T1差值（ΔT1）、T1值变化百分比高于损伤组，差异均具有统计学意义（P＜0.05）。实质区和水肿区T1+c、ΔT1、T1值变化百分比对鉴别HCG复发和放射性脑损伤的效能均较高，诊断准确率分别为91.8%、94.6%、94.6%、97.2%和97.2%。结论 合成MRI技术在鉴别HCG术后复发和放射性脑损伤方面具有较好的效能，可辅助临床制定后续治疗方案。 [国际神经病学神经外科学杂志, 2023, 50(6): 40-46]
Objective To investigate the application value of synthetic magnetic resonance imaging （MRI） in differentiating postoperative recurrence of high-grade gliomas （HCG） from radiation-induced brain injury.Methods This study was conducted among 41 patients who attended the Anyang District Hospital and The Second Affiliated Hospital of Xi’an Medical University from January 2018 to December 2022 and underwent radiotherapy after HCG surgery， and all patients underwent synthetic MRI scan and synthetic MRI contrast-enhanced scan， with a confirmed diagnosis based on secondary surgical pathology or MRI follow-up. The pre-enhancement T1 value （T1-pre） and T2 value （T2-pre） and the post-enhancement T1 value （T1+c） were measured for the parenchymal area and surrounding edema area of the lesion， and various parameters were compared between the recurrence group and the injury group. The receiver operating characteristic curve was plotted to evaluate the efficacy of each parameter in differentiating between recurrence and injury.Results A total of 37 patients were included in this study， among whom there were 21 patients with recurrence and 16 with radiation-induced brain injury. There were no significant differences in T1-pre and T2-pre of the parenchymal area and the edema area between the recurrence group and the brain injury group （P >0.05）. Compared with the injury group， the recurrence group had a significantly lower T1+c value of the parenchymal area and the edema area， a significantly greater difference in T1 before and after enhancement （ΔT1）， and a significantly higher percentage change in T1 value before and after enhancement （P <0.05）. T1+c， ΔT1， and the percentage change in T1 value in the parenchymal area and the edema area had relatively high efficacy in differentiating HCG recurrence from radiation-induced brain injury， with a diagnostic accuracy of 91.8%， 94.6%， 94.6%， 97.2%， and 97.2%， respectively.Conclusions Synthetic MRI technology has good efficacy in differentiating postoperative recurrence of HCG from radiation-induced brain injury， and can assist in the formulation of subsequent treatment regimens in clinical practice. ［Journal of International Neurology and Neurosurgery, 2023, 50(6): 40-46］
引用本文
刘艳玲,付星卉,潘奇,程晓艺,王勇,张沙沙,张俊丽,邵山峰456.合成MRI在高级别脑胶质瘤术后复发与放射性损伤鉴别中的应用[J].国际神经病学神经外科学杂志,2023,50(6):40-46111LIU Yanling, FU Xinghui, PAN Qi, CHENG Xiaoyi, WANG Yong, ZHANG Shasha, ZHANG Junli, SHAO Shanfeng222. Application of synthetic magnetic resonance imaging in differentiating postoperative recurrence of high-grade glioma from radiation-induced injury[J]. Journal of International Neurology and Neurosurgery,2023,50(6):40-46
复制分享
文章指标
- 点击次数:
- 下载次数:
历史
- 收稿日期:2023-02-25
- 最后修改日期:2023-12-13
- 录用日期:
- 在线发布日期: 2024-06-20
