Objective To investigate the association between the history of using aspirin and the occurrence of ruptured intracranial aneurysms.Methods A total of 177 patients with intracranial aneurysms who were hospitalized in Department of Neurology， Nanjing Jiangning Hospital， from January 2019 to April 2023 were enrolled. According to the presence or absence of ruptured intracranial aneurysms， the patients were divided into rupture group with 59 patients and non-rupture group with 118 patients； according to whether the patient took aspirin regularly before the diagnosis of intracranial aneurysms， they were divided into medication group with 82 patients and non-medication group with 95 patients. General clinical data and the data on intracranial aneurysms were collected， and the univariate analysis and the multivariate logistic regression analysis were used to investigate the impact of aspirin on the rupture of intracranial aneurysms.Results There were significant differences between the rupture group and the non-rupture group in the proportion of patients with hyperlipidemia or the history of using statins or aspirin （P<0.05）. After adjustment for age， gender， hypertension， smoking， hyperlipidemia， and history of using statin， the multivariate logistic regression analysis showed that history of using aspirin was a protective factor against ruptured intracranial aneurysms （odds ratio=0.235， 95% confidence interval： 0.102-0.541， P=0.001）. Compared with the non-medication group， the medication group had significantly lower levels of inflammatory factors （C-reactive protein and neutrophil-to-lymphocyte ratio） and a significantly lower proportion of patients with rupture of aneurysm （P<0.05）. The patients who had taken aspirin for >1 year had a significantly lower proportion of patients with rupture of aneurysm than those who had taken it for ≤1 year （P<0.05）.Conclusions History of using aspirin is closely associated with the rupture of intracranial aneurysms and serves as a protective factor against such rupture， which is considered to be associated with the anti-inflammatory effect of aspirin， and such protective effect is more significant in patients who have been taking aspirin for over one year. ［Journal of International Neurology and Neurosurgery, 2023, 50(6): 24-28］