1.新乡医学院，河南 新乡 453003;2.郑州大学附属郑州市中心医院神经内科，河南 郑州 450000
周曼曼，女，硕士研究生。
杨改清，女，主任医师，硕士研究生导师。Email：zxyyygq@163.com。
河南省科技研发专项资金（192102310082）；河南省医学科技攻关计划（联合共建）项目（LHGJ20191042）。
- ZHOU Manman 1,2
- XU Zhiqiang 1
- GAO Wenwen 1,2
- LI Yidi 1,2
- FU Juan 1,2
- YANG Gaiqing 1
1.Xinxiang Medical College， Xinxiang， Henan 453003， China;2.Department of Neurology， Zhengzhou Central Hospital Affiliated to Zhengzhou University， Zhengzhou， Henan 450000， China
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目的 探讨血清胰岛素样生长因子1（IGF-1）与帕金森病（PD）伴骨质疏松（OP）的相关性。方法 回顾性分析105例PD患者（PD组）和78例健康体检人群（HC组）的临床资料。比较2组一般临床资料及血清IGF-1水平的差异。根据双能X线吸收检测法（DXA）进行的骨密度检测结果将PD患者分为PD伴OP组（50例）与PD不伴OP组（55例）。比较2组一般临床资料及血清IGF-1水平的差异。采用皮尔逊相关系数分析血清IGF-1水平与腰椎骨密度及左侧股骨颈骨密度的相关性。采用多因素Logistic回归分析探讨PD伴OP的危险因素。结果 与HC组比较，PD组血清IGF-1水平显著降低（P<0.05）。皮尔逊相关系数分析结果显示，血清IGF-1水平与腰椎骨密度及左侧股骨颈骨密度呈正相关分别（r=0.653，P<0.001；r=0.625，P<0.001 ）。多因素Logistic回归分析显示，血清IGF-1、尿酸水平减低及H-Y分期增加是PD伴OP的危险因素（P<0.05）。结论 血清IGF-1、尿酸水平减低及H-Y分期增加与PD伴骨质疏松密切相关。提高血清IGF-1及UA水平可能成为PD伴骨质疏松潜在治疗方法。国际神经病学神经外科学杂志, 2023, 50(6): 7-12]
Objective To investigate the association between serum insulin-like growth factor-1 （IGF-1） and Parkinson's disease （PD） with osteoporosis （OP）.Methods A retrospective analysis was performed for the clinical data of 105 patients with PD （PD group） and 78 healthy controls （HC group）， and general clinical data and serum IGF-1 level were compared between the two groups. Dual-energy X-ray absorptiometry was used to measure bone mineral density （BMD）， and then the patients with PD were divided into PD+OP group with 50 patients and non-OP PD group with 55 patients； general clinical data and serum IGF-1 level were compared between the two groups. The Pearson correlation analysis was used to investigate the correlation of serum IGF-1 level with lumbar vertebral BMD and left femoral neck BMD， and the multivariate logistic regression analysis was used to investigate the risk factors for PD in patients with OP.Results Compared with the HC group， the PD group had a significant reduction in serum IGF-1 level （P<0.05）. The Pearson correlation analysis showed that serum IGF-1 level was positively correlated with lumbar vertebral BMD （r=0.653， P<0.001） and left femoral neck BMD （r=0.625， P<0.001）. The multivariate logistic regression analysis showed that the reductions in serum IGF-1 and uric acid （UA） and the increase in H-Y staging were risk factors for PD in patients with OP （P<0.05）.Conclusions The reductions in serum IGF-1 and UA and the increase in H-Y staging are closely associated with PD in patients with OP， and increasing the serum levels of IGF-1 and UA may be a potential therapeutic method for this disorder. ［Journal of International Neurology and Neurosurgery, 2023, 50(6): 7-12］
引用本文
周曼曼,徐志强,高雯雯,等.血清胰岛素样生长因子1与帕金森病伴骨质疏松的相关性研究[J].国际神经病学神经外科学杂志,2023,50(6):7-12.ZHOU M,XU Z,GAO W,et al. Association between serum insulin-like growth factor 1 and Parkinson’s disease with osteoporosis[J]. Journal of International Neurology and Neurosurgery,2023,50(6):7-12
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- 收稿日期:2023-06-12
- 最后修改日期:2023-10-24
- 在线发布日期: 2024-06-20
