Contrast-induced encephalopathy （CIE） is a rare， acute， and reversible nervous system disease and is associated with the intra-arterial injection of iodized contrast agents. This article retrospectively analyzes three patients who developed CIE after cerebrovascular intervention in Hunan Province Brain Hospital. Among the three patients， two had mental symptoms and one had altered consciousness； all three patients had limb weakness， and one had limb convulsions. Radiological examination suggested new-onset infarcts in three patients， contrast agent extravasation in one patient， and an increase in cerebral hemorrhage in one patient. After symptomatic treatment， two patients were improved and one patient had the sequela of limb weakness. Literature review showed that the clinical manifestations of CIE after cerebrovascular intervention included mental and behavioral disorders， impaired vision， hemiplegia， and aphasia， and imaging findings may include brain edema， new-onset cerebral infarction， and high-density and hyperintensity shadows in the subarachnoid space， while some patients may have no imaging abnormalities. Symptoms completely disappear in most patients after symptomatic treatment， while a few patients may have sequelae.