Objective To analyze and summarize the factors affecting hematoma enlargement in patients with cerebral amyloid angiopathy-related intracerebral hemorrhage during hospitalization， and to provide guidance for reducing its incidence.Methods The data of 242 patients admitted to neurosurgery， neurology， and emergency department who met the inclusion criteria from July 2016 to July 2023 were retrospectively analyzed. They were divided into hematoma enlargement group （n=48） and non-hematoma enlargement group （n=194）. A statistical analysis was performed for influencing factors.Results Multivariate logistic analysis showed that advanced age （OR： 1.064， 95% CI： 1.018-1.113， P=0.006）， high systolic blood pressure （OR： 1.063， 95% CI： 1.015-1.113， P=0.009）， Panax notoginseng drugs （OR： 5.078， 95% CI： 2.191-11.766， P＜0.001）， high blood calcium （OR： 0.033，95%CI： 0.005-0.202， P=0.033） difference was statistically significant.Conclusion Advanced age， high systolic blood pressure， Panax notoginseng drugs and high blood calcium were the influencing factors of hematoma enlargement in patients with cerebral amyloid angiopathy-related cerebral hemorrhage. Advanced age， high systolic blood pressure and Panax notoginseng drugs were risk factors， high blood calcium was protective factor.