老年颅内前循环动脉瘤显微外科手术治疗的效果
作者:
作者单位:

武汉大学中南医院神经外科,湖北 武汉 430071

作者简介:

汪乐生(1994—),男,汉族,博士在读,主要从事脑肿瘤和脑血管病方面基础和临床研究。Email:1763541656@qq.com。

通信作者:

杨邦坤(1981—),男,汉族,副主任医师,博士,主要从事脑肿瘤和脑血管病基础和临床研究。Email: bangkunyang@whu.edu.cn。

基金项目:

湖北省自然科学基金计划项目(2020CFB728)。


Effectiveness of microsurgery for intracranial anterior circulation aneurysms in elderly patients
Author:
Affiliation:

Department of Neurosurgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, China

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    摘要:

    目的 分析和比较不同年龄段老年患者颅内前循环动脉瘤的显微外科手术治疗效果和安全性。方法 回顾性分析2018年3月—2020年12月在武汉大学中南医院神经外科接受显微外科手术治疗的95例老年颅内前循环动脉瘤患者,根据年龄大小将患者分为2组:低龄老人组(60~70岁)和中龄老人组(≥70岁)。收集这些患者的基本信息、病史和临床数据,包括格拉斯哥昏迷量表(GCS)评分、改良Fisher分级(mFisher)、格拉斯哥结局量表(GOS)评分和改良Rankin量表(mRS)评分。结果 共纳入95例老年患者,所有患者平均年龄为(67.9±4.3)岁。两组患者在性别、合并症、GCS评分、Fisher评分、动脉瘤部位、动脉瘤有无破裂、动脉瘤形态和患者的动脉瘤数目、动脉瘤大小等方面比较,差异无统计学意义(P>0.05)。两组均接受显微外科夹闭术。术后低龄老人组和中龄老人组手术相关并发症的发生率分别为12%和35%(P=0.015),所有动脉瘤手术均达到影像学方面的完全闭塞。两组患者具有相似的GOS评分(P>0.999)和住院期间死亡率(P=0.512),且在随访期间的mRS评分也无统计学差异(P=0.677)。与中龄老人组相比,低龄老人组的住院费用更低(P=0.003)。两组患者随访期间影像学检查均未见动脉瘤复发。结论 对老年前循环动脉瘤患者,显微外科夹闭手术风险随着年龄的增长而增加;该术式对低龄老年患者是一种相对可行且相对安全的手术方式。

    Abstract:

    Objective To analyze the effectiveness and safety of microsurgery for intracranial anterior circulation aneurysms in elderly patients of different ages.Methods We reviewed 95 elderly patients undergoing microsurgery for intracranial anterior circulation aneurysms in the Department of Neurosurgery, Zhongnan Hospital of Wuhan University from March 2018 to December 2020. These patients were divided into younger group (60-69 years old) and older group (≥70 years old). We collected their data on basic information, medical history, and clinical data including Glasgow Coma Scale (GCS) score, modified Fisher scale (mFisher) score, Glasgow Outcome Scale (GOS) score, and modified Rankin Scale (mRS) score.Results The mean age of the 95 patients was 67.9±4.3 years. There were no significant differences in sex, comorbidities, GCS score, mFisher score, aneurysm location, the presence or absence of aneurysm rupture, and the morphology, number, and size of aneurysms between the two groups (P >0.05). Both groups underwent microsurgical clipping. The incidence rates of postoperative procedure-related complications in the two groups were 12% and 35%, respectively (P = 0.015). Complete occlusion was achieved on imaging for all the aneurysm procedures. The two groups showed no significant differences in GOS score (P >0.999), in-hospital mortality (P = 0.512), and mRS score at follow-up (P = 0.677). Hospital cost was significantly lower in the younger group than in the older group (P = 0.003). No recurrence of aneurysm was observed by imaging during follow-up between the two groups.Conclusions The risk of microsurgical clipping for anterior circulation aneurysms increases with age in elderly patients. Microsurgical clipping is a relatively feasible and safe procedure in the treatment of younger elderly patients with anterior circulation aneurysms.

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汪乐生,许双祥,段靖雯,陈劲草,杨邦坤456.老年颅内前循环动脉瘤显微外科手术治疗的效果[J].国际神经病学神经外科学杂志,2023,50(5):21-26111WANG Lesheng, XU Shuangxiang, DUAN Jingwen, CHEN Jincao, YANG Bangkun.222. Effectiveness of microsurgery for intracranial anterior circulation aneurysms in elderly patients[J]. Journal of International Neurology and Neurosurgery,2023,50(5):21-26

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  • 收稿日期:2022-03-25
  • 最后修改日期:2023-07-03
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  • 在线发布日期: 2023-11-30
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