The comorbidity of migraine and somatic symptom disorder is common in clinical practice， with severity influenced by each other. The possible comorbidity mechanisms involve central sensitization， abnormal brain functional connectivity， and dysfunction of the 5-hydroxytryptamine system. The common somatic symptoms of patients with migraine with somatic symptom disorder include fatigue， sleep difficulty， nausea or indigestion， extremity pain， dizziness， back pain， and chest pain. The comorbidity should be distinguished from non-headache symptoms of migraine as well as tension-type headache and new daily persistent headache with somatic symptoms. Migraine with somatic symptom disorder can be treated with antidepressants such as amitriptyline and venlafaxine， cognitive behavior therapy， and mindfulness-based therapy. ［Journal of International Neurology and Neurosurgery, 2023, 50(4): 95-100］