Acute ischemic stroke （AIS） is the most common type of stroke with high disability and mortality rates， and inflammatory response plays an important role in its pathophysiological process. Interleukin-20 （IL-20） participates in the development and progression of diseases such as rheumatoid arthritis， psoriasis， cancer， and atherosclerosis by promoting inflammatory response and angiogenesis. In the central nervous system， IL-20 is also involved in neuroinflammatory response， and in case of hypoxia in brain tissue， the level of IL-20 in the body can be upregulated to induce the expression of related pro-inflammatory factors， thereby promoting inflammatory response and exacerbating AIS. With reference to related studies in China and overseas in recent years， this article reviews the association between inflammatory response and AIS， the source and mechanism of action of IL-20， and the role of IL-20 in central nervous system disorders and discusses the association between IL-20 and AIS， so as to provide a reference for the development， prognosis， and treatment of AIS. ［Journal of International Neurology and Neurosurgery, 2023, 50(4): 76-79］