Objective To investigate the effect of computer rehabilitation therapeutic apparatus combined with ultra-early intensive exercise rehabilitation on motor function and quality of life in patients with stroke.Methods A total of 150 patients with stroke who were admitted to Beijing Luhe Hospital Affiliated to Capital Medical University， from June 2017 to September 2020 were selected and divided into observation group with 67 patients and control group with 74 patients. The patients in the control group received treatment with a computer rehabilitation therapeutic apparatus， and those in the observation group received ultra-early intensive exercise rehabilitation therapy in addition to the treatment in the control group. The two groups were compared in terms of simplified Fugl-Meyer Assessment （FMA） score， modified Ashworth score， Brunnstrom stage， General Quality of Life Inventory， coagulation function ［prothrombin time （PT） and prothrombin time activity （PTA）］， routine blood test results， and homocysteine level before and after treatment.Results After treatment， compared with the control group， the observation group had a significantly higher simplified FMA score （75.63±10.84 vs 47.29±8.75， P<0.05） and a significantly lower modified Ashworth score （0.57±0.13 vs 1.82±0.25， P<0.05）. After 3 months of treatment， compared with the control group， the observation group had a significantly higher proportion of patients with grade I/II disease （P<0.05） and a significantly lower proportion of patients with grade III/IV/V disease （P<0.05）. After 3 months of treatment， the observation group had a significantly better total quality of life score than the control group （73.21±4.98 vs 60.37±5.22， P<0.05）. After 3 months of treatment， compared with the control group， the observation group had significantly lower PTA level， white blood cell count， platelet count， and homocysteine level （P<0.05） and significantly higher levels of PT and hemoglobin （P<0.05）.Conclusions Computer rehabilitation therapeutic apparatus combined with ultra-early intensive exercise rehabilitation can improve the motor function， quality of life， and coagulation function in patients with stroke. ［Journal of International Neurology and Neurosurgery, 2023, 50(4): 34-39］