CircRNA在脑胶质瘤发生发展中的调控机制和应用研究进展
作者:
作者单位:

1.重庆大学医学院,重庆 400030;2.陆军军医大学第二附属医院神经外科,重庆 400037

作者简介:

周硕(1999—),女,硕士研究生在读,主要从事脑胶质瘤相关研究。

通信作者:

吕胜青(1971—),男,主任医师、教授,医学博士,博士生导师,主要从事脑肿瘤发生发展分子机制和临床治疗研究。Email: lvsq0518@hotmail.com。

基金项目:

国家自然科学基金面上项目(81972360);重庆英才创新创业领军人才(医学领域)(CQYC20200303149)。


Regulatory mechanism of circular RNA in the development and progression of glioma and related application and research advances
Author:
Affiliation:

1.School of Medicine, Chongqing University, Chongqing 400030, China;2.Department of Neurosurgery, Xinqiao Hospital, Army Medical University, Chongqing 400037, China

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    摘要:

    脑胶质瘤是颅内常见的原发性恶性肿瘤之一,其病情进展快、复发率高、预后差。环状RNA(circRNA)是一种特殊的非编码RNA,具有独特的稳定性、组织特异性及疾病特异性。有证据表明,大量异常表达的circRNA在脑胶质瘤细胞的增殖、侵袭、迁移和凋亡等过程中展现重要作用,被认为是脑胶质瘤早期诊断和预后评估的一种新型生物标志物,将为脑胶质瘤的预防、诊断和靶向治疗提供新的思路和手段。该文概述了circRNA在脑胶质瘤发生发展中的调控机制,并对circRNA在脑胶质瘤临床诊疗应用研究的最新进展进行综述。 [国际神经病学神经外科学杂志, 2023, 50(3): 66-72]

    Abstract:

    Glioma is a common primary intracranial malignancy characterized by rapid progression, high recurrence rate, and poor prognosis. Circular RNA (circRNA) is a special type of non-coding RNA and has unique stability, tissue specificity, and disease specificity. Current evidence has shown that abnormally expressed circRNAs play an important role in the proliferation, invasion, migration, and apoptosis of glioma cells and are considered novel biomarkers for the early diagnosis and prognostic evaluation of glioma, which provides new ideas and methods for the prevention, diagnosis, and targeted treatment of glioma. This article reviews the regulatory mechanism of circRNA in the development and progression of glioma and the latest advances in the application of circRNA in the clinical diagnosis and treatment of glioma. [Journal of International Neurology and Neurosurgery, 2023, 50(3): 66-72]

    Fig.
    图2 circRNA在脑胶质瘤诊断上的应用及部分已应用的脑胶质瘤circRNA分子诊断标志物Fig.2
    图3 circRNA在脑胶质瘤靶向药物治疗及耐药机制研究上的应用Fig.3
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周硕,张作鑫,任鹏,曹勇勇,吕胜青456. CircRNA在脑胶质瘤发生发展中的调控机制和应用研究进展[J].国际神经病学神经外科学杂志,2023,50(3):66-72111ZHOU Shuo, ZHANG Zuoxin, REN Peng, CAO Yongyong, Lü Shengqing222. Regulatory mechanism of circular RNA in the development and progression of glioma and related application and research advances[J]. Journal of International Neurology and Neurosurgery,2023,50(3):66-72

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  • 收稿日期:2023-01-05
  • 最后修改日期:2023-04-23
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  • 在线发布日期: 2023-08-16
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