Objective To construct a health intervention consortium for elderly patients with post-stroke hemiplegia during rehabilitation， and to investigate its practice effect.Methods A total of 93 elderly patients with post-stroke hemiplegia who were admitted to the Second Affiliated Hospital of Anhui Medical University from January 2020 to August 2021 were enrolled and randomly divided into control group with 46 patients and research group with 47 patients. The patients in the control group received routine health intervention during rehabilitation， while those in the research group received intervention with a health intervention consortium during rehabilitation. The two groups were compared in terms of National Institutes of Health Stroke Scale （NIHSS） score， simplified Fugl-Meyer Assessment （FMA） score， modified Barthel index， 10-meter walk time test （10MWT）， Stroke-Specific Quality of Life （SS-QOL） score， and timed up and go test （TUGT） time on admission， on the day of discharge， and at 3 months after discharge， and compliance was also compared between the two groups.Results Compared with the control group， the research group had significantly lower NIHSS score， 10MWT， and TUGT （P<0.05） and significantly higher FMA score， modified Barthel index， and SS-QOL score （P<0.05） on the day of discharge and at 3 months after discharge. The study group had a significantly higher good compliance rate than the control group （P<0.05）.Conclusions For the elderly patients with post-stroke hemiplegia， intervention based on a health intervention consortium during rehabilitation can reduce neurological defects， promote the improvement in limb motor function， walking ability， and activities of daily living， and increase compliance and quality of life. ［Journal of International Neurology and Neurosurgery, 2023, 50(3): 32-36］