非钠离子快速纠正的脑桥中央髓鞘溶解的临床分析
作者:
作者单位:

1.湖南中医药大学附属省直中医医院,湖南 株洲 412000;2.湖南中医药高等专科学校附属第一医院神经内科,湖南 株洲 412000;3.湖南中医药高等专科学校附属第一医院放射科,湖南 株洲 412000

作者简介:

王旭锋(1995―),男,在读硕士,从事神经系统疾病的重症治疗。Email:1282984559@qq.com。

通信作者:

彭永(1970―),男,硕士研究生导师,副主任医师,从事神经系统疾病研究。Email:1779342446@qq.com。

基金项目:

湖南省中医药管理局重点课题(201915);湖南省卫计委课题(B20180815);湖南中医药高等专科学校附属第一医院优秀科研创新团队(B2021-003);株洲市科技计划项目(2021-009,2021/01–2023/12)。


A clinical analysis of central pontine myelinolysis not caused by rapid correction of sodium ion abnormalities
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Affiliation:

1.Provincial Traditional Chinese Medicine Hospital of Hunan University of Traditional Chinese Medicine, Zhuzhou, Hunan 412000, China;2.Department of Neurology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China;3.Department of Radiology, Affiliated First Hospital of Hunan Traditional Chinese Medical College, Zhuzhou, Hunan 412000, China

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    摘要:

    脑桥中央髓鞘溶解(central pontine myelinolysis,CPM)是一种临床较为罕见的疾病,通常导致该病的原因是钠离子异常的快速纠正。该文报道了3例并非由钠离子快速纠正导致的CPM,其中2例为极高血糖并酮症酸中毒引起的,1例为钾离子过低引起的。经过治疗原发病和营养脑神经后,患者均好转出院。该文总结了这3个病例的临床特点,同时总结分析了国内外CPM相关的研究进展,希望能提高对于该病的认识。 [国际神经病学神经外科学杂志, 2023, 50(2): 49-52]

    Abstract:

    Central pontine myelinolysis (CPM) is a relatively rare disease in clinical practice and is often caused by the rapid correction of sodium ion abnormalities. This article reports three cases of CPM not caused by the rapid correction of sodium ion abnormalities, among which two cases were caused by extremely high blood glucose and ketoacidosis and one case was caused by low potassium ion. All patients were improved and discharged after the treatment of primary diseases and the nutrition of brain nerves. This article summarizes the features of these three cases and reviews related research advances in CPM, so as to improve the awareness of this disease. [Journal of International Neurology and Neurosurgery, 2023, 50(2): 49-52]

    表 1 3例患者的临床基本特点Table 1
    图1 病例2颅脑MRI平扫+DWI结果(脑桥)Fig.1
    图2 病例3治疗前颅脑MRI平扫+DWI所见(脑桥见大片状稍长T1稍长T2高FLAIR信号,DWI呈高ADC呈低信号,其周围见对称性片状等T1长T2高FLAIR信号)Fig.2
    图3 病例3治疗后颅脑MRI平扫+DWI所见(脑桥见片状稍长T1稍长T2高FLAIR信号,范围较前缩小,DWI信号较前减低)Fig.3
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王旭锋,彭永,甘棋心,唐艳丹,李拥军,张镇群456.非钠离子快速纠正的脑桥中央髓鞘溶解的临床分析[J].国际神经病学神经外科学杂志,2023,50(2):49-52111WANG Xufeng, PENG Yong, GAN Qixin, TANG Yandan, LI Yongjun, ZHANG Zhenqun222. A clinical analysis of central pontine myelinolysis not caused by rapid correction of sodium ion abnormalities[J]. Journal of International Neurology and Neurosurgery,2023,50(2):49-52

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  • 收稿日期:2022-03-25
  • 最后修改日期:2023-01-09
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  • 在线发布日期: 2023-07-06
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