Objective To investigate the safety and efficacy of low-profile visualized intraluminal support （LVIS） stent in the treatment of symptomatic middle cerebral artery stenosis.Methods A retrospective analysis was performed for 23 patients with symptomatic middle cerebral artery stenosis who were treated with LVIS stent in Department of Cerebrovascular Intervention， Zhongshan City People’s Hospital， from June 2018 to June 2021 and had complete follow-up data. The success rate of surgery， complications， and in-stent restenosis were recorded， and the patients were followed up for 6-32 months.Results The stents were successfully released in all 23 patients. Among these patients， 1 patient developed distant reperfusion bleeding after surgery and was improved after active conservative treatment； 1 patient had stent thrombosis and was improved after aspiration； 1 patient still had transient ischemic attack with in-stent restenosis found by angiography and had a good outcome after balloon dilatation angioplasty. There were significant changes in stenosis rate and National Institutes of Health Stroke Scale score after surgery （P <0.05）.Conclusions LVIS stent is feasible and effective in the treatment of symptomatic middle cerebral artery stenosis. ［Journal of International Neurology and Neurosurgery, 2023, 50(2): 44-48］