Glioma is a highly malignant and invasive intracranial primary tumor， and tumor invasion and metastasis is the main cause of poor prognosis. Epithelial-mesenchymal transition （EMT） is the key process for glioma cells to obtain the phenotypic characteristics of strong migration and invasion abilities. As an evolutionarily conserved cellular development process， EMT is closely associated with carcinogenic effect. This article reviews the mechanism of action of EMT in the invasion and migration of glioma and related targeted therapy， so as to provide a theoretical basis for the diagnosis and treatment of glioma.