Objective To summarize the feasibility and reliability sellar dural suture technique in endoscopic transsphenoidal sellar region tumors resection.Methods Clinical data of 28 patients with sellar region tumors who underwent endoscopic transsphenoidal sellar region tumors resection from January 2019 to July 2021 were analyzed retrospectively. And literature review was also carried out.Results All the 28 patients had intraoperative CSF leakage. According to Kelly grading method， 14 cases of Grade 1 CSF leakage， 10 cases of Grade 2 CSF leakage and 4 cases of Grade 3 CSF leakage occurred intraoperatively. All cases were accepted the dural suture technique to repair the saddle base. In the last 27 patients， primary skull base reconstruction was successful without postoperative cerebrospinal fluid leakage. One patient with Rathkes cyst had postoperative cerebrospinal fluid leakage， and the endoscopic cerebrospinal fluid leakage repair was performed again and there was no postoperative leakage.Conclusions Suture the dura of the skull base， which can produce a large support force for the skull base， and the reconstruction effect is definite， which is worthy of clinical application.