Circular RNAs （circRNAs） are a type of non-coding RNAs that are widely expressed in eukaryotic cells. CircRNAs can be generated by circularization after back-splicing wherein the downstream 5′ splice site is joined to the upstream 3′ splice site of a single or multiple exons in a gene， and thus they are more stable than linear RNA. Many experimental results have confirmed that circRNAs are involved in the regulation of malignant tumors in various systems including the nervous， digestive， endocrine， and urinary systems and play an important role in the development and progression of these tumors. In recent years， a series of non-coding RNAs represented by circRNAs have become a hotspot in the research on their mechanisms in regulating central nervous system （CNS） malignancies in children， and they are expected to become new targets for the targeted therapy for CNS tumors in children and provide new ideas for early diagnosis and improvement in the prognosis of children. ［Journal of International Neurology and Neurosurgery, 2022, 49(6): 97-101］