Cerebral ischemia-reperfusion （I/R） can lead to varying degrees of injury， which is the main reason for the deterioration of ischemic stroke， with the features of high incidence rate， high recurrence rate， high disability rate， and high mortality rate. Once it occurs， it is likely to cause serious brain dysfunction. Cerebral ischemia-reperfusion has a complex etiology， and related molecular mechanism is still unclear. At present， thrombolytic therapy is the main treatment method for this disease， but the strict limits on time window lead to the low rate of thrombolytic therapy， and therefore， exploring more effective treatment means will reduce the pain caused by such disease. Tripartite motif （TRIM） proteins are important regulatory factors for cell survival， apoptosis， and oxidative stress， and some studies have reported that some proteins in the TRIM family play an important role in the inflammatory response stage of cerebral ischemia-reperfusion injury （CIRI）， but related mechanism remains unclear. This article reviews the related mechanisms of TRIM family in CIRI， so as to provide a reference for subsequent studies. ［Journal of International Neurology and Neurosurgery, 2022, 49(6): 77-81］